Configuration and leishmanicidal activity of (-)-argentilactone epoxides.
نویسندگان
چکیده
Epoxidation of argentilactone (1) with m-chloroperbenzoic acid gave a diasteromeric mixture of 2 and 3 in a ratio 1.8 : 1, with total yield 60%. The configuration of 7,8-oxirane ring for both diasteromers was determined by NMR analysis. Reaction of 1 with urea hydrogen peroxide gave the 3,4-epoxide (4) in 65% yield. The in vitro activity of 2, 3, 4 and argentilactone against Leishmania amazonensis was tested, only epoxides (2) and (3) showed leishmanicidal effect.
منابع مشابه
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ورودعنوان ژورنال:
- Natural product research
دوره 20 11 شماره
صفحات -
تاریخ انتشار 2006